Women's Wellness Insider
5 things to know about GHK-Cu before you buy another serum
What menopausal collagen loss is, why GHK-Cu addresses it, and why nothing else in your routine does.
1
What you're dealing with is menopausal collagen loss. GHK-Cu addresses it.
Most women don't call it that. They call it crepey skin, or fine lines, or their face changing. Some are told it's just ageing.
It's one thing, and it has a cause.
Estrogen holds a great deal of your skin's structure in place — collagen density, elastin, thickness. When estrogen falls in the years around perimenopause, that structure falls with it. A large share of the total loss lands in a few years rather than spread across decades, which is why so many women can name the year it happened.
That's menopausal collagen loss. The crepiness, the texture change, the makeup sitting differently, the skin that doesn't spring back.
Nothing on a normal skincare shelf is built for it. That shelf was built for slow ageing and sun damage.
"I'm 47 and I now look and feel like I aged 10 to 15 years overnight."
"I swear my skin has changed more in the last 10 months than in the previous 10 years."
2
Your body already makes GHK-Cu. It tells skin to build collagen.
It's a copper peptide, found in human blood in 1973 by researchers looking at why aged tissue behaved younger when exposed to young blood.
Its job is repair signalling. It tells fibroblasts — the cells that build collagen and elastin — to get to work. It's been studied for wound healing ever since.
Collagen sits in the dermis, the layer underneath the surface of your skin. That's where the loss happens, and that's where GHK-Cu works. It doesn't replace estrogen and it can't stop that decline.
What it does is stimulate collagen production directly, in the layer that thinned.
It isn't a new synthetic active. It's something your skin has been using its whole life.
"How have I never heard of this? I've been using vitamin C and moisturiser for twenty years."
3
Moisturisers and vitamin C never reach the dermis. GHK-Cu does.
This is where most women spend a year or more treating the wrong problem.
Moisturiser hydrates the epidermis — the surface layer. Hyaluronic acid holds water in it. Vitamin C is an antioxidant working largely at the surface. All three do exactly what they're designed to do, and none of them are designed to reach the layer underneath.
Collagen supplements have the same problem from the other end — digested protein doesn't arrive at your face as collagen.
They were built for dryness and dullness. Menopausal collagen loss is neither.
"No matter how much moisturiser or oil I put on, my skin is always dry."
"I've used every cream under the sun and I'm just about to spend a fortune on supplements."
4
Retinol, peels and lasers reach it by damaging skin. GHK-Cu doesn't have to.
These do work, and the evidence behind them is real. But look at how they work.
Retinoids force turnover. Acids strip the surface. Peels are a controlled burn. Lasers and RF use heat. Microneedling makes small injuries. Every one provokes the skin into repairing itself, and the repair is what produces the collagen.
That's a fair trade when your skin can afford it.
After menopausal collagen loss, thinner skin often can't handle it — which is why the retinol that was comfortable at 38 stings at 48.
GHK-Cu doesn't provoke anything. Nothing to purge, nothing to peel, nothing to sting.
"Products I used for years suddenly started stinging."
"Suddenly every single moisturizer, including the hypoallergenic one, makes the skin around my eyes and cheeks burn and sting."
5
Nothing in a normal routine stimulates collagen. GHK-Cu does.
Look at a typical shelf. Cleanser, hydrating serum, vitamin C, moisturiser, SPF, maybe a retinoid, maybe a collagen powder.
Every one of those is either working on the surface or working through damage. Not one is directly stimulating collagen in the layer that thinned.
Your routine isn't wrong. It just isn't treating the real issue.
Menopausal collagen loss is what happened. Nothing on that shelf treats it.
"I've been so diligent and consistent with no progress."
"I spent like thousands of dollars on skincare products with zero results."
What to look for
GHK-Cu appears on labels as copper tripeptide-1. In studies on ageing skin, topical copper peptides increased skin thickness, elasticity and collagen production. In one head-to-head measuring procollagen, a copper peptide outperformed both vitamin C and tretinoin.
What matters is the dose and what else is in the bottle. You don't need a twelve-step routine — you need the one step that's missing, in a formula with nothing in it that's going to set your skin off.
Lanarie Native Serum
50mg GHK-Cu Copper Peptide · 30ml
- 50mg of GHK-Cu. Copper tripeptide-1, the peptide that stimulates collagen.
- Works in the dermis. The layer moisturiser and vitamin C can't reach.
- Nothing that stings. No retinol, no acids, no fragrance. Nothing to purge or peel.
- One active, nothing else. So you know exactly what's working.
- Layers under everything. Twice a day after cleansing. Keep the rest of your routine.
90-day money-back guarantee.
What to expect
Two things happen on two different clocks. One you'll feel the same night.
12 weeks apart
Skin changes slowly enough that you won't catch it in the mirror. Side by side is where most women see it.
Same face, same light, same camera, 12 weeks apart. Twice daily use.
Individual results vary. Unretouched photos.
What women using it say
I'd got to the point where everything I put on my face stung. This is the first thing in two years that didn't.
★★★★★ Karen M.
My makeup stopped sitting right about a year ago and I blamed the foundation. Bought three new ones. It was never the foundation.
★★★★★ Diane R.
I'm 51. Twelve weeks in and my cheeks don't have that crinkled look anymore. My daughter noticed before I did.
★★★★★ Susan T.
Menopausal collagen loss is the crepiness, the texture change and the makeup sitting differently. It's one thing, and estrogen is the cause.
GHK-Cu is a copper peptide your body already makes. It stimulates collagen in the dermis — the layer where the loss happened.
Moisturiser and vitamin C work on the surface. Retinol, peels and lasers reach deeper by damaging skin first.
GHK-Cu does neither. Nothing to purge, peel or sting.
Your routine isn't wrong. It just isn't treating the real issue.
Claim offer →Special Offer Today. 90-day money-back guarantee, even on an open bottle.
References
- Pickart L, Thaler MM. Tripeptide in human serum which prolongs survival of normal liver cells and stimulates growth in neoplastic liver. Nature New Biology 1973;243(124):85–87.
- Pickart L, Vasquez-Soltero JM, Margolina A. GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration. BioMed Research International 2015;2015:648108.
- Pickart L, Margolina A. The potential of GHK as an anti-aging peptide. Plasma GHK averages approximately 200 ng/mL at age 20, declining to approximately 80 ng/mL by age 60.
- Abdulghani AA et al. Effects of topical creams containing vitamin C, a copper-binding peptide cream and melatonin compared with tretinoin on the ultrastructure of normal skin. Disease Management & Clinical Outcomes 1998;1(4):136–141.
- Thornton MJ. Estrogens and aging skin. Dermato-Endocrinology 2013;5(2):264–270.
- Brincat M et al. Long-term effects of the menopause and sex hormones on skin thickness. British Journal of Obstetrics and Gynaecology.
This page is an advertisement. It is not a news article, a consumer report, or an independent product review. It was produced and paid for by Lanarie, which sells the product described above. Other products and product categories are described here for comparison only.
Research described on this page relates to the ingredient GHK-Cu and to the biology of skin during and after the menopausal transition. It is not a study of Lanarie Native Serum. Ingredient research does not establish that any cosmetic product produces a particular result.
Lanarie Native Serum is a cosmetic product intended to moisturise and improve the appearance of skin. It is not intended to diagnose, treat, cure or prevent any disease, is not a hormone treatment, and is not a substitute for HRT or any medication prescribed to you. It does not replace lost volume beneath the skin and does not lift or tighten facial structure.
Quotes attributed to women in this article are taken from public online skincare and menopause communities and are used to illustrate common experiences. They are not customer reviews of this product.
Customer reviews are individual experiences and are not a guarantee that you will get the same result. Results vary and depend on skin type, routine, and consistency of use.
This page is for general information and is not medical advice. If you have concerns about your skin or your hormones, speak to a doctor.
Lanarie Native Serum contains Copper Tripeptide-1 (GHK-Cu) and Sodium Hyaluronate. No retinol, no exfoliating acids, no added fragrance.
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